Proteolysis regulates cardiomyocyte maturation and tissue integration

Ryuichi Fukuda; Felix Gunawan; Arica Beisaw; Vanesa Jimenez-Amilburu; Hans-Martin Maischein; Sawa Kostin; Koichi Kawakami; Didier Y. R. Stainier

doi:10.1038/ncomms14495

Nature Communications (Feb 2017)

Proteolysis regulates cardiomyocyte maturation and tissue integration

Ryuichi Fukuda,
Felix Gunawan,
Arica Beisaw,
Vanesa Jimenez-Amilburu,
Hans-Martin Maischein,
Sawa Kostin,
Koichi Kawakami,
Didier Y. R. Stainier

Affiliations

Ryuichi Fukuda: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Felix Gunawan: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Arica Beisaw: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Vanesa Jimenez-Amilburu: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Hans-Martin Maischein: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Sawa Kostin: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Koichi Kawakami: Division of Molecular and Developmental Biology, National Institute of Genetics
Didier Y. R. Stainier: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research

DOI: https://doi.org/10.1038/ncomms14495
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Proper heart development and synchronous cardiomyocyte contraction rely on tissue integrity. Here the authors show that the ubiquitin-proteasome system and the E3 ubiquitin ligase ASB2 in particular are crucial for cardiomyocyte maturation and tissue integrity through the degradation of the TCF3 transcription factor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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