Nature Communications (Jun 2016)
Alterations of the human gut microbiome in multiple sclerosis
- Sushrut Jangi,
- Roopali Gandhi,
- Laura M. Cox,
- Ning Li,
- Felipe von Glehn,
- Raymond Yan,
- Bonny Patel,
- Maria Antonietta Mazzola,
- Shirong Liu,
- Bonnie L. Glanz,
- Sandra Cook,
- Stephanie Tankou,
- Fiona Stuart,
- Kirsy Melo,
- Parham Nejad,
- Kathleen Smith,
- Begüm D. Topçuolu,
- James Holden,
- Pia Kivisäkk,
- Tanuja Chitnis,
- Philip L. De Jager,
- Francisco J. Quintana,
- Georg K. Gerber,
- Lynn Bry,
- Howard L. Weiner
Affiliations
- Sushrut Jangi
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Roopali Gandhi
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Laura M. Cox
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Ning Li
- Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School
- Felipe von Glehn
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Raymond Yan
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Bonny Patel
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Maria Antonietta Mazzola
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Shirong Liu
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Bonnie L. Glanz
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Sandra Cook
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Stephanie Tankou
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Fiona Stuart
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Kirsy Melo
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Parham Nejad
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Kathleen Smith
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Begüm D. Topçuolu
- Department of Microbiology, University of Massachusetts
- James Holden
- Department of Microbiology, University of Massachusetts
- Pia Kivisäkk
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Tanuja Chitnis
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Philip L. De Jager
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Francisco J. Quintana
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- Georg K. Gerber
- Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School
- Lynn Bry
- Department of Pathology, Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School
- Howard L. Weiner
- Department of Neurology, Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/ncomms12015
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes.
