CPEB1 directs muscle stem cell activation by reprogramming the translational landscape

Wenshu Zeng; Lu Yue; Kim S. W. Lam; Wenxin Zhang; Wai-Kin So; Erin H. Y. Tse; Tom H. Cheung

doi:10.1038/s41467-022-28612-1

Nature Communications (Feb 2022)

CPEB1 directs muscle stem cell activation by reprogramming the translational landscape

Wenshu Zeng,
Lu Yue,
Kim S. W. Lam,
Wenxin Zhang,
Wai-Kin So,
Erin H. Y. Tse,
Tom H. Cheung

Affiliations

Wenshu Zeng: Division of Life Science, The Hong Kong University of Science and Technology
Lu Yue: Division of Life Science, The Hong Kong University of Science and Technology
Kim S. W. Lam: Division of Life Science, The Hong Kong University of Science and Technology
Wenxin Zhang: Division of Life Science, The Hong Kong University of Science and Technology
Wai-Kin So: Division of Life Science, The Hong Kong University of Science and Technology
Erin H. Y. Tse: Division of Life Science, The Hong Kong University of Science and Technology
Tom H. Cheung: Division of Life Science, The Hong Kong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-28612-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Skeletal muscle stem cells are actively maintained in quiescence, but can activate quickly upon extrinsic stimulation. Here the authors show that CPEB1 promotes muscle stem cell activation by reprogramming the translational landscape.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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