Clinical pathological analysis of ocular adnexal lymphoma

Abstract

AIM: To study the incidence, clinical features and pathological types of ocular adnexal lymphoma(OAL), in order to improve the level of clinical diagnosis and treatment.METHODS: There were 147 cases of OAL in West China Hospital from August 2005 to July 2013. We collected clinical data such as general conditions, clinical manifestations, clinical examination(imaging, pathology)results, treatment and prognosis for retrospective study.RESULTS: This study consist of 147 patients with OAL, including 91 males(61.9%)and 56 females(38.1%); aged from 3.5 to 87 years old; the course of disease range from 20d to 10a; the most common location of disease is orbit(106/147).The most common clinical manifestations including ocular mass, eyelid swelling and exophthalmos. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue were most common(112/147), it also had the best prognosis while diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma,nasal type showed the worst prognosis.CONCLUSION: The pathological types of OAL were complex, which also had diverse location of disease and clinical manifestations. Immunohistochemically staining is an important basis for the differential diagnosis of OAL, and the prognosis of which is closely related to pathological type.

Keywords

• ocular adnexal lymphoma
• clinic
• pathology