Photothermal induced chemo-immunological synergistic therapy for anaplastic thyroid carcinoma treatment

Bowen Chen; Hua Zhang; Jia Wei; Zhenshengnan Li; Yaoqi Wang; Yunkai Bao; Minghong Jian; Huimao Zhang; Zhenxin Wang; Xianying Meng

Materials & Design (May 2023)

Photothermal induced chemo-immunological synergistic therapy for anaplastic thyroid carcinoma treatment

Bowen Chen,
Hua Zhang,
Jia Wei,
Zhenshengnan Li,
Yaoqi Wang,
Yunkai Bao,
Minghong Jian,
Huimao Zhang,
Zhenxin Wang,
Xianying Meng

Affiliations

Bowen Chen: Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, PR China
Hua Zhang: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
Jia Wei: Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, PR China
Zhenshengnan Li: Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, PR China
Yaoqi Wang: Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, PR China
Yunkai Bao: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Science and Technology of China, Hefei 230026, China
Minghong Jian: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Science and Technology of China, Hefei 230026, China
Huimao Zhang: Department of Radiology, The First Hospital of Jilin University, Changchun 130021, PR China
Zhenxin Wang: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Science and Technology of China, Hefei 230026, China; National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China
Xianying Meng: Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, PR China

Journal volume & issue: Vol. 229
p. 111859

Abstract

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It is still of great challenge for anaplastic thyroid carcinoma (ATC) treatment since ATC is an extremely destructive and lethal thyroid malignancy. Herein, a kind of multifunctional nanoplatform (denoted as PDA-dsCpG-DOX NP) has been prepared and applied for tri-modal ATC therapy including photothermal therapy (PTT), chemotherapy, and immunotherapy. Polydopamine nanoparticle (PDA NP) serves as a photothermal agent to generate PTT, as well as a carrier of doxorubicin (DOX) and immunotherapeutic DNA (i.e., oligonucleotide comprising unmethylated cytosine-phosphate-guanine dinucleotide (CpG ODN)). The high temperature induced by PTT results in the release of CpG ODNs for immunotherapy and the liberation of DOX for chemotherapy. PDA-dsCpG-DOX NPs exhibit a phenomenal collaborative therapy effect contrasted with a corresponding single therapy or dual-modal treatment. By use of mice bearing C643 thyroid tumors as a model, PDA-dsCpG-DOX NPs have been demonstrated to realize nearly complete tumor growth suppression with good biocompatibility. Hence, PDA-dsCpG-DOX NPs introduce a synergistic scheme for ATC treatment and foreground the congregate effects of tri-modal therapy.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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