Фундаментальная и клиническая медицина (Jun 2018)

MANAGEMENT OF PREGNANT WOMEN WITH LARGE UTERINE FIBROIDS

  • SERGEY V. Barinov,
  • INNA V. Shamina,
  • YULIA I. Tirskaya,
  • OKSANA V. Lazareva,
  • GALINA V. Dudkovа,
  • EKATERINA A. Frickel,
  • INNA O. Ledovskikh,
  • MARIA I. Shishkina,
  • TAMARA А. Stotskaya

Journal volume & issue
Vol. 3, no. 2
pp. 34 – 41

Abstract

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Aim. To test whether a combination of pessary and micronized progesterone improves pregnancy management and delivery outcomes in pregnant women with large uterine fibroids. Materials and Methods. We collected the data on pregnancy course and birth outcome of 102 patients with large uterine fibroids who were further stratified into two groups: 1) those having 5-7 cm diameter uteroids (n = 45); 2) those having 8-10 cm diameter uteroids (n = 57). All patients underwent uterine myomectomy during pregnancy with the following administration of both pessary and micronized progesterone (200 mg/day vaginally). Results. The risk of abortion was 73.5% (75/102). Pain was documented in 91.0% (91/100) of patients while 39.0% (39/100) of patients had impaired blood supply of the fibroid. Preterm birth occurred in 10.0% (10/100) cases that is 1.9-fold less as compared to the average rate for Russia in patients with uterine fibroids (18.6%). Conclusion. A combination of pessary with micronized progesterone can significantly reduce the incidence of preterm birth.

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