Chemogenetic ON and OFF switches for RNA virus replication

E. Heilmann; J. Kimpel; B. Hofer; A. Rössler; I. Blaas; L. Egerer; T. Nolden; C. Urbiola; H. G. Kräusslich; G. Wollmann; D. von Laer

doi:10.1038/s41467-021-21630-5

Nature Communications (Mar 2021)

Chemogenetic ON and OFF switches for RNA virus replication

E. Heilmann,
J. Kimpel,
B. Hofer,
A. Rössler,
I. Blaas,
L. Egerer,
T. Nolden,
C. Urbiola,
H. G. Kräusslich,
G. Wollmann,
D. von Laer

Affiliations

E. Heilmann: Institute of Virology, Medical University of Innsbruck
J. Kimpel: Institute of Virology, Medical University of Innsbruck
B. Hofer: Institute of Virology, Medical University of Innsbruck
A. Rössler: Institute of Virology, Medical University of Innsbruck
I. Blaas: Institute of Virology, Medical University of Innsbruck
L. Egerer: Institute of Virology, Medical University of Innsbruck
T. Nolden: Institute of Virology, Medical University of Innsbruck
C. Urbiola: Institute of Virology, Medical University of Innsbruck
H. G. Kräusslich: Department of Infectious Diseases, Virology, University Hospital Heidelberg
G. Wollmann: Institute of Virology, Medical University of Innsbruck
D. von Laer: Institute of Virology, Medical University of Innsbruck

DOI: https://doi.org/10.1038/s41467-021-21630-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Therapeutic application of RNA viruses requires tight control over viral activity. Here the authors design a regulatory switch that enables control over activity with clinically approved HIV protease inhibitors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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