Nature Communications (Mar 2016)

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation

  • Diana Langer,
  • Igor Martianov,
  • Daniel Alpern,
  • Muriel Rhinn,
  • Céline Keime,
  • Pascal Dollé,
  • Gabrielle Mengus,
  • Irwin Davidson

DOI
https://doi.org/10.1038/ncomms11063
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

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The role of TFIID core module TAFs (TATA-binding protein-associated factors) in embryogenesis is unknown. Here, the authors show that Taf4 is essential at mid-gestation and for complete neuronal differentiation of embryonic stem cells, but that Taf4a and Taf4b are redundant at early embryonic stages.