Molecules
(Jan 2018)
Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex
Yu Xia,
Chuan-Zeng Wang,
Mengkui Tian,
Zhu Tao,
Xin-Long Ni,
Timothy J. Prior,
Carl Redshaw
Affiliations
Yu Xia
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Chuan-Zeng Wang
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Mengkui Tian
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Zhu Tao
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Xin-Long Ni
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Timothy J. Prior
Department of Chemistry, School of Mathematics and Physical Sciences, University of Hull, Hull HU6 7RX, UK
Carl Redshaw
Department of Chemistry, School of Mathematics and Physical Sciences, University of Hull, Hull HU6 7RX, UK
DOI
https://doi.org/10.3390/molecules23010175
Journal volume & issue
Vol. 23,
no. 1
Abstract
Read online
The host-guest interaction of a series of cyclohexyl-appended guests with cucurbit[8]uril (Q[8]) was studied by 1H NMR spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The X-ray structure revealed that two cycloalkane moieties can be simultaneously encapsulated in the hydrophobic cavity of the Q[8] host to form a ternary complex for the first time.
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