Structure and dynamics of the active Gs-coupled human secretin receptor

Maoqing Dong; Giuseppe Deganutti; Sarah J. Piper; Yi-Lynn Liang; Maryam Khoshouei; Matthew J. Belousoff; Kaleeckal G. Harikumar; Christopher A. Reynolds; Alisa Glukhova; Sebastian G. B. Furness; Arthur Christopoulos; Radostin Danev; Denise Wootten; Patrick M. Sexton; Laurence J. Miller

doi:10.1038/s41467-020-17791-4

Nature Communications (Aug 2020)

Structure and dynamics of the active Gs-coupled human secretin receptor

Maoqing Dong,
Giuseppe Deganutti,
Sarah J. Piper,
Yi-Lynn Liang,
Maryam Khoshouei,
Matthew J. Belousoff,
Kaleeckal G. Harikumar,
Christopher A. Reynolds,
Alisa Glukhova,
Sebastian G. B. Furness,
Arthur Christopoulos,
Radostin Danev,
Denise Wootten,
Patrick M. Sexton,
Laurence J. Miller

Affiliations

Maoqing Dong: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic
Giuseppe Deganutti: School of Biological Sciences, University of Essex
Sarah J. Piper: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Yi-Lynn Liang: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Maryam Khoshouei: Department of Molecular Structural Biology, Max Planck Institute of Biochemistry
Matthew J. Belousoff: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Kaleeckal G. Harikumar: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic
Christopher A. Reynolds: School of Biological Sciences, University of Essex
Alisa Glukhova: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Sebastian G. B. Furness: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Arthur Christopoulos: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Radostin Danev: Graduate School of Medicine, University of Tokyo
Denise Wootten: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Patrick M. Sexton: Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
Laurence J. Miller: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic

DOI: https://doi.org/10.1038/s41467-020-17791-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

Read online

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal