Nature Communications (Nov 2021)
The genetic architecture of DNA replication timing in human pluripotent stem cells
- Qiliang Ding,
- Matthew M. Edwards,
- Ning Wang,
- Xiang Zhu,
- Alexa N. Bracci,
- Michelle L. Hulke,
- Ya Hu,
- Yao Tong,
- Joyce Hsiao,
- Christine J. Charvet,
- Sulagna Ghosh,
- Robert E. Handsaker,
- Kevin Eggan,
- Florian T. Merkle,
- Jeannine Gerhardt,
- Dieter Egli,
- Andrew G. Clark,
- Amnon Koren
Affiliations
- Qiliang Ding
- Department of Molecular Biology and Genetics, Cornell University
- Matthew M. Edwards
- Department of Molecular Biology and Genetics, Cornell University
- Ning Wang
- Department of Pediatrics, Columbia University
- Xiang Zhu
- Department of Statistics, Pennsylvania State University
- Alexa N. Bracci
- Department of Molecular Biology and Genetics, Cornell University
- Michelle L. Hulke
- Department of Molecular Biology and Genetics, Cornell University
- Ya Hu
- Department of Molecular Biology and Genetics, Cornell University
- Yao Tong
- Department of Molecular Biology and Genetics, Cornell University
- Joyce Hsiao
- Department of Human Genetics, University of Chicago
- Christine J. Charvet
- Department of Molecular Biology and Genetics, Cornell University
- Sulagna Ghosh
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Robert E. Handsaker
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Kevin Eggan
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Florian T. Merkle
- Wellcome Trust - Medical Research Council Institute of Metabolic Science, University of Cambridge
- Jeannine Gerhardt
- Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine
- Dieter Egli
- Department of Pediatrics, Columbia University
- Andrew G. Clark
- Department of Molecular Biology and Genetics, Cornell University
- Amnon Koren
- Department of Molecular Biology and Genetics, Cornell University
- DOI
- https://doi.org/10.1038/s41467-021-27115-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
