Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

Jason E. Martinez; Doron D. Kahana; Doron D. Kahana; Simran Ghuman; Haley P. Wilson; Julian Wilson; Samuel C. J. Kim; Venu Lagishetty; Venu Lagishetty; Jonathan P. Jacobs; Jonathan P. Jacobs; Jonathan P. Jacobs; Amiya P. Sinha-Hikim; Amiya P. Sinha-Hikim; Theodore C. Friedman; Theodore C. Friedman

doi:10.3389/fendo.2021.667066

Frontiers in Endocrinology (Jun 2021)

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

Jason E. Martinez,
Doron D. Kahana,
Doron D. Kahana,
Simran Ghuman,
Haley P. Wilson,
Julian Wilson,
Samuel C. J. Kim,
Venu Lagishetty,
Venu Lagishetty,
Jonathan P. Jacobs,
Jonathan P. Jacobs,
Jonathan P. Jacobs,
Amiya P. Sinha-Hikim,
Amiya P. Sinha-Hikim,
Theodore C. Friedman,
Theodore C. Friedman

Affiliations

Jason E. Martinez: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Doron D. Kahana: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Doron D. Kahana: Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States
Simran Ghuman: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Haley P. Wilson: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Julian Wilson: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Samuel C. J. Kim: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Venu Lagishetty: Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States
Venu Lagishetty: David Geffen School of Medicine at University of California, UCLA Microbiome Center, Los Angeles, CA, United States
Jonathan P. Jacobs: Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States
Jonathan P. Jacobs: David Geffen School of Medicine at University of California, UCLA Microbiome Center, Los Angeles, CA, United States
Jonathan P. Jacobs: Division of Gastroenterology, Hepatology and Parenteral Nutrition, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, United States
Amiya P. Sinha-Hikim: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Amiya P. Sinha-Hikim: Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States
Theodore C. Friedman: Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States
Theodore C. Friedman: Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States

DOI: https://doi.org/10.3389/fendo.2021.667066
Journal volume & issue: Vol. 12

Abstract

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The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention. Bidirectional communication between gut microbes and the host can impact numerous biological systems regulating immunity and metabolism to either promote or negatively impact the host’s health. Habitual routines, dietary choices, socioeconomic status, education, host genetics, medical care and environmental factors can all contribute to the composition of an individual’s microbiome. A key environmental factor that may cause negative outcomes is the consumption of nicotine products. The effects of nicotine on the host can be exacerbated by poor dietary choices and together can impact the composition of the gut microbiota to promote the development of metabolic disease including non-alcoholic fatty liver disease. This review explores the contribution of nicotine, poor dietary choices and other unhealthy lifestyle factors to gut dysbiosis.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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