Nature Communications (Mar 2020)

Housing temperature influences exercise training adaptations in mice

  • Steffen H. Raun,
  • Carlos Henriquez-Olguín,
  • Iuliia Karavaeva,
  • Mona Ali,
  • Lisbeth L. V. Møller,
  • Witold Kot,
  • Josué L. Castro-Mejía,
  • Dennis Sandris Nielsen,
  • Zachary Gerhart-Hines,
  • Erik A. Richter,
  • Lykke Sylow

DOI
https://doi.org/10.1038/s41467-020-15311-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Exercise has been shown to be an effective approach to ameliorate metabolic disease in mice housed at ambient temperatures, a condition of mild cold stress to mice. Here the authors show that molecular and metabolic adaptations to exercise are blunted when mice are housed in thermoneutral conditions.