Communications Biology (Feb 2021)
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
- Steven Bell,
- Andreas S. Rigas,
- Magnus K. Magnusson,
- Egil Ferkingstad,
- Elias Allara,
- Gyda Bjornsdottir,
- Anna Ramond,
- Erik Sørensen,
- Gisli H. Halldorsson,
- Dirk S. Paul,
- Kristoffer S. Burgdorf,
- Hannes P. Eggertsson,
- Joanna M. M. Howson,
- Lise W. Thørner,
- Snaedis Kristmundsdottir,
- William J. Astle,
- Christian Erikstrup,
- Jon K. Sigurdsson,
- Dragana Vuckovic,
- Khoa M. Dinh,
- Vinicius Tragante,
- Praveen Surendran,
- Ole B. Pedersen,
- Brynjar Vidarsson,
- Tao Jiang,
- Helene M. Paarup,
- Pall T. Onundarson,
- Parsa Akbari,
- Kaspar R. Nielsen,
- Sigrun H. Lund,
- Kristinn Juliusson,
- Magnus I. Magnusson,
- Michael L. Frigge,
- Asmundur Oddsson,
- Isleifur Olafsson,
- Stephen Kaptoge,
- Henrik Hjalgrim,
- Gudmundur Runarsson,
- Angela M. Wood,
- Ingileif Jonsdottir,
- Thomas F. Hansen,
- Olof Sigurdardottir,
- Hreinn Stefansson,
- David Rye,
- DBDS Genomic Consortium,
- James E. Peters,
- David Westergaard,
- Hilma Holm,
- Nicole Soranzo,
- Karina Banasik,
- Gudmar Thorleifsson,
- Willem H. Ouwehand,
- Unnur Thorsteinsdottir,
- David J. Roberts,
- Patrick Sulem,
- Adam S. Butterworth,
- Daniel F. Gudbjartsson,
- John Danesh,
- Søren Brunak,
- Emanuele Di Angelantonio,
- Henrik Ullum,
- Kari Stefansson
Affiliations
- Steven Bell
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Andreas S. Rigas
- Department of Clinical Immunology, Copenhagen University Hospital
- Magnus K. Magnusson
- deCODE genetics/Amgen Inc.
- Egil Ferkingstad
- deCODE genetics/Amgen Inc.
- Elias Allara
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Gyda Bjornsdottir
- deCODE genetics/Amgen Inc.
- Anna Ramond
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Erik Sørensen
- Department of Clinical Immunology, Copenhagen University Hospital
- Gisli H. Halldorsson
- deCODE genetics/Amgen Inc.
- Dirk S. Paul
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Kristoffer S. Burgdorf
- Department of Clinical Immunology, Copenhagen University Hospital
- Hannes P. Eggertsson
- deCODE genetics/Amgen Inc.
- Joanna M. M. Howson
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Lise W. Thørner
- Department of Clinical Immunology, Copenhagen University Hospital
- Snaedis Kristmundsdottir
- deCODE genetics/Amgen Inc.
- William J. Astle
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Christian Erikstrup
- Department of Clinical Immunology, Aarhus University Hospital
- Jon K. Sigurdsson
- deCODE genetics/Amgen Inc.
- Dragana Vuckovic
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Khoa M. Dinh
- Department of Clinical Immunology, Aarhus University Hospital
- Vinicius Tragante
- deCODE genetics/Amgen Inc.
- Praveen Surendran
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Ole B. Pedersen
- Department of Clinical Immunology, Næstved Hospital
- Brynjar Vidarsson
- The Laboratory in Mjodd, RAM
- Tao Jiang
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Helene M. Paarup
- Department of Clinical Immunology, Odense University Hospital
- Pall T. Onundarson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Parsa Akbari
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Kaspar R. Nielsen
- Department of Clinical Immunology, Aalborg University Hospital
- Sigrun H. Lund
- deCODE genetics/Amgen Inc.
- Kristinn Juliusson
- deCODE genetics/Amgen Inc.
- Magnus I. Magnusson
- deCODE genetics/Amgen Inc.
- Michael L. Frigge
- deCODE genetics/Amgen Inc.
- Asmundur Oddsson
- deCODE genetics/Amgen Inc.
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali, the National University Hospital of Iceland
- Stephen Kaptoge
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Henrik Hjalgrim
- Department of Epidemiology Research, Statens Serum Institut
- Gudmundur Runarsson
- The Laboratory in Mjodd, RAM
- Angela M. Wood
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Thomas F. Hansen
- Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup
- Olof Sigurdardottir
- Department of Clinical Biochemistry, Akureyri Hospital
- Hreinn Stefansson
- deCODE genetics/Amgen Inc.
- David Rye
- Department of Neurology and Program in Sleep, Emory University School of Medicine
- DBDS Genomic Consortium
- James E. Peters
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- David Westergaard
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Nicole Soranzo
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Karina Banasik
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Gudmar Thorleifsson
- deCODE genetics/Amgen Inc.
- Willem H. Ouwehand
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- David J. Roberts
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Patrick Sulem
- deCODE genetics/Amgen Inc.
- Adam S. Butterworth
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- John Danesh
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Søren Brunak
- Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Emanuele Di Angelantonio
- The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Henrik Ullum
- Department of Clinical Immunology, Copenhagen University Hospital
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- DOI
- https://doi.org/10.1038/s42003-020-01575-z
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Bell et al. report 46 new loci associated with biomarkers of iron homeostasis, including ferritin levels, iron binding capacity, and iron saturation, in the Icelandic, Danish and UK populations. The associated loci point to new iron-regulating proteins and important genetic differences between men and women.
