Nature Communications (Jul 2017)

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

  • Nacho Aguilo,
  • Jesus Gonzalo-Asensio,
  • Samuel Alvarez-Arguedas,
  • Dessislava Marinova,
  • Ana Belen Gomez,
  • Santiago Uranga,
  • Ralf Spallek,
  • Mahavir Singh,
  • Regine Audran,
  • François Spertini,
  • Carlos Martin

DOI
https://doi.org/10.1038/ncomms16085
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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MTBVAC, a live attenuatedMycobacterium tuberculosisvaccine under clinical evaluation, contains the major tuberculosis antigens ESAT6 and CFP10, which are absent from the current vaccine, BCG. Here, the authors show that these antigens contribute to enhanced vaccine efficacy in mouse models.