Clinical and Experimental Gastroenterology (May 2022)
Decreased Rate of Presentation, but Worsened Racial-Ethnic Disparity in Acute Gastrointestinal Bleeding During Coronavirus 2019 Shutdown: A Retrospective Cohort Study
Abstract
Sumana Reddy,1 Beyla Patel,2 Luke Baldelli,3 Rajiv T Majithia,4 Michael K Dougherty3,4 1Department of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; 2School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; 3Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA; 4Rex Digestive Healthcare, UNC REX Healthcare, Raleigh, NC, USACorrespondence: Michael K Dougherty, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, 4182 Bioinformatics, 130 Mason Farm Road, Chapel Hill, NC, 27599-6134, USA, Tel +1 984-215-4672, Fax +1 919-590-6724, Email [email protected]: In spring 2020, Coronavirus Disease 2019 (COVID-19) “stay-at-home” orders may have led to later, more acute disease presentations of emergent conditions such as gastrointestinal bleeding (GIB). In this retrospective cohort study, we compared incidence and severity of GIB during the strictest COVID shutdown to pre-COVID periods.Patients and methods: We compared weekly counts of emergency department (ED) visits for GIB between March 27 and May 7, 2020 (COVID period) and pre-COVID periods in 2019 and 2020 in a US statewide network of hospitals. We compared the severity of GIB presentations using incident rate ratios (IRR) of “severe” GIB (requiring ≥ 4 units of blood, endoscopic therapy, interventional radiology or surgical procedure), intensive care (ICU) admission and shock. We also looked for effect modification of demographic covariates on associations between year and GIB outcomes.Results: Fewer patients presented to ED for GIB during COVID than during the same dates in 2019 (534 versus 904; IRR 0.59, 95% CI 0.53– 0.66). A greater proportion of COVID-period ED visits required inpatient admission (73.6% vs 67.8%, p = 0.02) and had severe GIB (19.3% vs 14.9%, p = 0.03). Proportion of patients requiring transfusion (p < 0.001), with shock (p < 0.01), or with critical hemoglobin (p = 0.003) or lactate (p = 0.02) were worse during COVID. Non-white patients experienced disproportionately worse outcomes during COVID than in 2019, with greater absolute counts of shock (65 vs 62, p = 0.01 for interaction) or ICU admission (40 vs 35, p = 0.01 for interaction).Conclusion: Fewer acute GIB presented during the pandemic period compared to the year prior. The severity of pandemic presentations was greater, driven by disproportionately worse outcomes in minorities.Keywords: SARS-CoV-2 lockdown, collateral damage, health disparities, GI bleed
