BMC Infectious Diseases (Jan 2024)
An analysis of differences in Carbapenem-resistant Enterobacterales in different regions: a multicenter cross-sectional study
- Bo Guo,
- Peili Li,
- Bingyu Qin,
- Shanmei Wang,
- Wenxiao Zhang,
- Yuan Shi,
- Jianxu Yang,
- Jingjing Niu,
- Shifeng Chen,
- Xiao Chen,
- Lin Cui,
- Qizhi Fu,
- Lin Guo,
- Zhe Hou,
- Hua Li,
- Xiaohui Li,
- Ruifang Liu,
- Xiaojun Liu,
- Zhengrong Mao,
- Xingguo Niu,
- Chao Qin,
- Xianrong Song,
- Rongqing Sun,
- Tongwen Sun,
- Daoxie Wang,
- Yong Wang,
- Lanjuan Xu,
- Xin Xu,
- Yuejie Yang,
- Baoquan Zhang,
- Dongmin Zhou,
- Zhaozhen Li,
- Yinyin Chen,
- Yue Jin,
- Juan Du,
- Huanzhang Shao
Affiliations
- Bo Guo
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Peili Li
- Department of Public Utilities Development, Henan Provincial People’s Hospital
- Bingyu Qin
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Shanmei Wang
- Department of Microbiology Laboratory, Henan Provincial People’s Hospital
- Wenxiao Zhang
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Yuan Shi
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Jianxu Yang
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Jingjing Niu
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Shifeng Chen
- Department of Critical Care Medicine, The Second People’s Hospital of Pingdingshan City
- Xiao Chen
- Department of Critical Care Medicine, Nanyang Nanshi Hospital
- Lin Cui
- Department of Critical Care Medicine, Yellow River Central Hospital
- Qizhi Fu
- Department of Critical Care Medicine, The First Affiliated Hospital of Henan University of Science and Technology
- Lin Guo
- Department of Critical Care Medicine, The Seventh People’s Hospital of Zhengzhou
- Zhe Hou
- Department of Critical Care Medicine, Zhengzhou Orthopedic Hospital
- Hua Li
- Department of Critical Care Medicine, Henan Provincial Hospital of Traditional Chinese Medicine
- Xiaohui Li
- Department of Critical Care Medicine, Fuwai Central China Cardiovascular Hospital
- Ruifang Liu
- Department of Critical Care Medicine, The Third People’s Hospital of Henan Province
- Xiaojun Liu
- Department of Critical Care Medicine, The Second Affiliated Hospital of Zhengzhou University
- Zhengrong Mao
- Department of Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine
- Xingguo Niu
- Department of Critical Care Medicine, Zhengzhou People’s Hospital
- Chao Qin
- Department of Critical Care Medicine, The Fifth Affiliated Hospital of Zhengzhou University
- Xianrong Song
- Department of Critical Care Medicine, Henan Provincial Chest Hospital
- Rongqing Sun
- Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University
- Tongwen Sun
- Department of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University
- Daoxie Wang
- Department of Critical Care Medicine, The Third People’s Hospital of Zhengzhou
- Yong Wang
- Department of Critical Care Medicine, Huaihe Hospital of Henan University
- Lanjuan Xu
- Department of Critical Care Medicine, Zhengzhou Central Hospital
- Xin Xu
- Department of Critical Care Medicine, The First Affiliated Hospital of Henan University
- Yuejie Yang
- Department of Critical Care Medicine, The Sixth People’s Hospital of Zhengzhou
- Baoquan Zhang
- Department of Critical Care Medicine, The Third Affiliated Hospital of Xinxiang Medical College
- Dongmin Zhou
- Department of Critical Care Medicine, Henan Cancer Hospital
- Zhaozhen Li
- Department of Critical Care Medicine, Henan Provincial Chest Hospital
- Yinyin Chen
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Yue Jin
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Juan Du
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- Huanzhang Shao
- Department of Critical Care Medicine, Henan Key Laboratory for Critical Care Medicine, Zhengzhou Key Laboratory for Critical Care Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University
- DOI
- https://doi.org/10.1186/s12879-024-09005-9
- Journal volume & issue
-
Vol. 24,
no. 1
pp. 1 – 8
Abstract
Abstract Objective This study aimed to explore the characteristics of carbapenem-resistant Enterobacterales (CRE) patients in the intensive care unit (ICU) in different regions of Henan Province to provide evidence for the targeted prevention and treatment of CRE. Methods This was a cross-sectional study. CRE screening was conducted in the ICUs of 78 hospitals in Henan Province, China, on March 10, 2021. The patients were divided into provincial capital hospitals and nonprovincial capital hospitals for comparative analysis. Results This study involved 1009 patients in total, of whom 241 were CRE-positive patients, 92 were in the provincial capital hospital and 149 were in the nonprovincial capital hospital. Provincial capital hospitals had a higher rate of CRE positivity, and there was a significant difference in the rate of CRE positivity between the two groups. The body temperature; immunosuppressed state; transfer from the ICU to other hospitals; and use of enemas, arterial catheters, carbapenems, or tigecycline at the provincial capital hospital were greater than those at the nonprovincial capital hospital (P < 0.05). However, there was no significant difference in the distribution of carbapenemase strains or enzymes between the two groups. Conclusions The detection rate of CRE was significantly greater in provincial capital hospitals than in nonprovincial capital hospitals. The source of the patients, invasive procedures, and use of advanced antibiotics may account for the differences. Carbapenem-resistant Klebsiella pneumoniae (CR-KPN) was the most prevalent strain. Klebsiella pneumoniae carbapenemase (KPC) was the predominant carbapenemase enzyme. The distributions of carbapenemase strains and enzymes were similar in different regions.
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