Nature Communications (Feb 2020)
Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation
- Panpan Hou,
- Po Wei Kang,
- Audrey Deyawe Kongmeneck,
- Nien-Du Yang,
- Yongfeng Liu,
- Jingyi Shi,
- Xianjin Xu,
- Kelli McFarland White,
- Mark A. Zaydman,
- Marina A. Kasimova,
- Guiscard Seebohm,
- Ling Zhong,
- Xiaoqin Zou,
- Mounir Tarek,
- Jianmin Cui
Affiliations
- Panpan Hou
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Po Wei Kang
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Audrey Deyawe Kongmeneck
- Université de Lorraine, CNRS, LPCT
- Nien-Du Yang
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Yongfeng Liu
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Jingyi Shi
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Xianjin Xu
- Dalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Informatics Institute, University of Missouri – Columbia
- Kelli McFarland White
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Mark A. Zaydman
- Department of Pathology and Immunology, Washington University School of Medicine
- Marina A. Kasimova
- Université de Lorraine, CNRS, LPCT
- Guiscard Seebohm
- Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster
- Ling Zhong
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- Xiaoqin Zou
- Dalton Cardiovascular Research Center, Department of Physics and Astronomy, Department of Biochemistry, Informatics Institute, University of Missouri – Columbia
- Mounir Tarek
- Université de Lorraine, CNRS, LPCT
- Jianmin Cui
- Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-020-14406-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-dependent activation.
