Communications Biology (Nov 2021)
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
- Winston A. Haynes,
- Kathy Kamath,
- Joel Bozekowski,
- Elisabeth Baum-Jones,
- Melissa Campbell,
- Arnau Casanovas-Massana,
- Patrick S. Daugherty,
- Charles S. Dela Cruz,
- Abhilash Dhal,
- Shelli F. Farhadian,
- Lynn Fitzgibbons,
- John Fournier,
- Michael Jhatro,
- Gregory Jordan,
- Jon Klein,
- Carolina Lucas,
- Debra Kessler,
- Larry L. Luchsinger,
- Brian Martinez,
- M. Catherine Muenker,
- Lauren Pischel,
- Jack Reifert,
- Jaymie R. Sawyer,
- Rebecca Waitz,
- Elsio A. Wunder,
- Minlu Zhang,
- Yale IMPACT Team,
- Akiko Iwasaki,
- Albert Ko,
- John C. Shon
Affiliations
- Winston A. Haynes
- Serimmune, Inc.
- Kathy Kamath
- Serimmune, Inc.
- Joel Bozekowski
- Serimmune, Inc.
- Elisabeth Baum-Jones
- Serimmune, Inc.
- Melissa Campbell
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Arnau Casanovas-Massana
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Patrick S. Daugherty
- Serimmune, Inc.
- Charles S. Dela Cruz
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine
- Abhilash Dhal
- Serimmune, Inc.
- Shelli F. Farhadian
- Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Lynn Fitzgibbons
- Santa Barbara Cottage Hospital
- John Fournier
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Michael Jhatro
- Serimmune, Inc.
- Gregory Jordan
- Serimmune, Inc.
- Jon Klein
- Department of Immunobiology, Yale University School of Medicine
- Carolina Lucas
- Department of Immunobiology, Yale University School of Medicine
- Debra Kessler
- New York Blood Center
- Larry L. Luchsinger
- New York Blood Center
- Brian Martinez
- Serimmune, Inc.
- M. Catherine Muenker
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Lauren Pischel
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Jack Reifert
- Serimmune, Inc.
- Jaymie R. Sawyer
- Serimmune, Inc.
- Rebecca Waitz
- Serimmune, Inc.
- Elsio A. Wunder
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Minlu Zhang
- Serimmune, Inc.
- Yale IMPACT Team
- Akiko Iwasaki
- Department of Immunobiology, Yale University School of Medicine
- Albert Ko
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- John C. Shon
- Serimmune, Inc.
- DOI
- https://doi.org/10.1038/s42003-021-02835-2
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.
