HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

Sébastien Gauvrit; Alethia Villasenor; Boris Strilic; Philip Kitchen; Michelle M. Collins; Rubén Marín-Juez; Stefan Guenther; Hans-Martin Maischein; Nana Fukuda; Maurice A. Canham; Joshua M. Brickman; Clifford W. Bogue; Padma-Sheela Jayaraman; Didier Y. R. Stainier

doi:10.1038/s41467-018-05039-1

Nature Communications (Jul 2018)

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

Sébastien Gauvrit,
Alethia Villasenor,
Boris Strilic,
Philip Kitchen,
Michelle M. Collins,
Rubén Marín-Juez,
Stefan Guenther,
Hans-Martin Maischein,
Nana Fukuda,
Maurice A. Canham,
Joshua M. Brickman,
Clifford W. Bogue,
Padma-Sheela Jayaraman,
Didier Y. R. Stainier

Affiliations

Sébastien Gauvrit: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Alethia Villasenor: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Boris Strilic: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Philip Kitchen: Institute of Cancer and Genomic Sciences, University of Birmingham
Michelle M. Collins: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Rubén Marín-Juez: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Stefan Guenther: ECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research
Hans-Martin Maischein: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Nana Fukuda: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Maurice A. Canham: School of Biological Sciences, Institute for Stem Cell Research, MRC Centre for Regenerative Medicine
Joshua M. Brickman: Novo Nordisk Foundation Centre for Stem Cell Biology (DanStem), University of Copenhagen
Clifford W. Bogue: Department of Pediatrics, Yale University School of Medicine
Padma-Sheela Jayaraman: Institute of Cancer and Genomic Sciences, University of Birmingham
Didier Y. R. Stainier: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research

DOI: https://doi.org/10.1038/s41467-018-05039-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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VEGFC, its receptor FLT4, and transcriptional effector PROX1 control formation of the lymphatic system but how is unclear. Here, the authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting and lymphatic formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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