Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder

Peifen Zhang; Peifen Zhang; Lingzhuo Kong; Huimin Huang; Yanmeng Pan; Danhua Zhang; Jiajun Jiang; Yuting Shen; Caixi Xi; Jianbo Lai; Jianbo Lai; Jianbo Lai; Jianbo Lai; Chee H. Ng; Shaohua Hu; Shaohua Hu; Shaohua Hu; Shaohua Hu

doi:10.3389/fnins.2022.830748

Frontiers in Neuroscience (Mar 2022)

Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder

Peifen Zhang,
Peifen Zhang,
Lingzhuo Kong,
Huimin Huang,
Yanmeng Pan,
Danhua Zhang,
Jiajun Jiang,
Yuting Shen,
Caixi Xi,
Jianbo Lai,
Jianbo Lai,
Jianbo Lai,
Jianbo Lai,
Chee H. Ng,
Shaohua Hu,
Shaohua Hu,
Shaohua Hu,
Shaohua Hu

Affiliations

Peifen Zhang: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Peifen Zhang: MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
Lingzhuo Kong: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Huimin Huang: Department of Psychiatry, Wenzhou Medical University, Wenzhou, China
Yanmeng Pan: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Danhua Zhang: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jiajun Jiang: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yuting Shen: Department of Psychiatry, Wenzhou Medical University, Wenzhou, China
Caixi Xi: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jianbo Lai: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jianbo Lai: MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
Jianbo Lai: The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, China
Jianbo Lai: Brain Research Institute, Zhejiang University, Hangzhou, China
Chee H. Ng: Department of Psychiatry, The Melbourne Clinic and St Vincent’s Hospital, University of Melbourne, Richmond, VIC, Australia
Shaohua Hu: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Shaohua Hu: MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
Shaohua Hu: The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, China
Shaohua Hu: Brain Research Institute, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fnins.2022.830748
Journal volume & issue: Vol. 16

Abstract

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Bipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut and brain function, which together form the gut-brain axis (GBA). Recent studies have shown that changes in the gut microbiota have been observed in a large number of BD patients, so the axis may play a role in the pathogenesis of BD. This review summarizes briefly the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and further explores the potential role of GBA-related pathway in the pathogenesis of BD as well as the limitations in this field at present in order to provide new ideas for the future etiology research and drug development.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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