Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

Courtney K. Brock; Stephen T. Wallin; Oscar E. Ruiz; Krystin M. Samms; Amrita Mandal; Elizabeth A. Sumner; George T. Eisenhoffer

doi:10.1038/s41467-019-09010-6

Nature Communications (Mar 2019)

Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

Courtney K. Brock,
Stephen T. Wallin,
Oscar E. Ruiz,
Krystin M. Samms,
Amrita Mandal,
Elizabeth A. Sumner,
George T. Eisenhoffer

Affiliations

Courtney K. Brock: Department of Genetics, The University of Texas MD Anderson Cancer Center
Stephen T. Wallin: Department of Genetics, The University of Texas MD Anderson Cancer Center
Oscar E. Ruiz: Department of Genetics, The University of Texas MD Anderson Cancer Center
Krystin M. Samms: Department of Genetics, The University of Texas MD Anderson Cancer Center
Amrita Mandal: Department of Genetics, The University of Texas MD Anderson Cancer Center
Elizabeth A. Sumner: Department of Genetics, The University of Texas MD Anderson Cancer Center
George T. Eisenhoffer: Department of Genetics, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-019-09010-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Damaged epithelial tissues are known to compensate for cell death through compensatory cell divisions to maintain epithelial integrity. Here, the authors show in living epithelia that dying cells stimulate adjacent stem cells to divide through caspase-dependent production of Wnt8a-containing apoptotic bodies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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