Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy
Huiqun Huang,
Ronghui Liu,
Jie Yang,
Jing Dai,
Shuhao Fan,
Jiang Pi,
Yubo Wei,
Xinrong Guo
Affiliations
Huiqun Huang
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China
Ronghui Liu
School of Microelectronic, Southern University of Science and Technology, Shenzhen 518000, China
Jie Yang
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China
Jing Dai
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China
Shuhao Fan
Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China
Jiang Pi
Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China
Yubo Wei
Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China
Xinrong Guo
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China
Cancer immunotherapy is an innovative treatment strategy to enhance the ability of the immune system to recognize and eliminate cancer cells. However, dose limitations, low response rates, and adverse immune events pose significant challenges. To address these limitations, gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing to their stability, surface versatility, and excellent optical properties. This review provides an overview of the advanced synthesis routes for AuNPs and their utilization as drug carriers to improve precision therapies. The review also emphasises various aspects of AuNP-based immunotherapy, including drug loading, targeting strategies, and drug release mechanisms. The application of AuNPs combined with cancer immunotherapy and their therapeutic efficacy are briefly discussed. Overall, we aimed to provide a recent understanding of the advances, challenges, and prospects of AuNPs for anticancer applications.
