Nature Communications (Jan 2017)

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

  • Shi Jiao,
  • Chuanchuan Li,
  • Qian Hao,
  • Haofei Miao,
  • Lei Zhang,
  • Lin Li,
  • Zhaocai Zhou

DOI
https://doi.org/10.1038/ncomms14058
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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The Wnt/β-catenin and YAP signaling pathways have fundamental roles in cancer. Here, the authors show that VGLL4, a known YAP antagonist, also negatively regulates Wnt/β-catenin signaling by targeting TEAD-DNA-TCF4 complex, thereby inhibiting colorectal cancer growth.