Nature Communications (Feb 2023)
Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice
- Shengchang Zhang,
- Ying Liu,
- Weiqiang Jing,
- Qihao Chai,
- Chunwei Tang,
- Ziyang Li,
- Zhentao Man,
- Chen Chen,
- Jing Zhang,
- Peng Sun,
- Rui Zhang,
- Zhenmei Yang,
- Maosen Han,
- Yan Wang,
- Xia Wei,
- Jun Li,
- Wei Li,
- Mohnad Abdalla,
- Gongchang Yu,
- Bin Shi,
- Yuankai Zhang,
- Kun Zhao,
- Xinyi Jiang
Affiliations
- Shengchang Zhang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Ying Liu
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Weiqiang Jing
- Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Qihao Chai
- Department of orthopaedic surgery, Shandong Provincial Hospital Affiliated to Shandong University
- Chunwei Tang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Ziyang Li
- Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Zhentao Man
- Department of orthopaedic surgery, Shandong Provincial Hospital Affiliated to Shandong University
- Chen Chen
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Jing Zhang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Peng Sun
- Shandong University of Traditional Chinese Medicine
- Rui Zhang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Zhenmei Yang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Maosen Han
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Yan Wang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Xia Wei
- Department of Pharmacology and Toxicology, Shandong Institute for Food and Drug Control
- Jun Li
- Department of Pharmacology and Toxicology, Shandong Institute for Food and Drug Control
- Wei Li
- Department of orthopaedic surgery, Shandong Provincial Hospital Affiliated to Shandong University
- Mohnad Abdalla
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Gongchang Yu
- Neck-Shoulder and Lumbocrural Pain Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences
- Bin Shi
- Neck-Shoulder and Lumbocrural Pain Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences
- Yuankai Zhang
- Department of orthopaedic surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Kun Zhao
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- Xinyi Jiang
- NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University
- DOI
- https://doi.org/10.1038/s41467-023-36468-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Proinflammatory macrophages are involved in rheumatoid arthritis (RA). Here the authors use an efferocytosis-mimetic self-deliverable nanoimitator to mitigate RA by targeted reprogramming of synovial inflammatory macrophages, reducing proinflammatory cytokines and reinstating articular immune homeostasis.
