Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Remco V. Klaassen; Jasper Stroeder; Françoise Coussen; Anne-Sophie Hafner; Jennifer D. Petersen; Cedric Renancio; Leanne J. M. Schmitz; Elisabeth Normand; Johannes C. Lodder; Diana C. Rotaru; Priyanka Rao-Ruiz; Sabine Spijker; Huibert D. Mansvelder; Daniel Choquet; August B. Smit

doi:10.1038/ncomms10682

Nature Communications (Mar 2016)

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Remco V. Klaassen,
Jasper Stroeder,
Françoise Coussen,
Anne-Sophie Hafner,
Jennifer D. Petersen,
Cedric Renancio,
Leanne J. M. Schmitz,
Elisabeth Normand,
Johannes C. Lodder,
Diana C. Rotaru,
Priyanka Rao-Ruiz,
Sabine Spijker,
Huibert D. Mansvelder,
Daniel Choquet,
August B. Smit

Affiliations

Remco V. Klaassen: Department Molecular and Cellular Neurobiology
Jasper Stroeder: Department Molecular and Cellular Neurobiology
Françoise Coussen: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
Anne-Sophie Hafner: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
Jennifer D. Petersen: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
Cedric Renancio: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
Leanne J. M. Schmitz: Department Molecular and Cellular Neurobiology
Elisabeth Normand: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
Johannes C. Lodder: Department Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University
Diana C. Rotaru: Department Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University
Priyanka Rao-Ruiz: Department Molecular and Cellular Neurobiology
Sabine Spijker: Department Molecular and Cellular Neurobiology
Huibert D. Mansvelder: Department Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University
Daniel Choquet: University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297
August B. Smit: Department Molecular and Cellular Neurobiology

DOI: https://doi.org/10.1038/ncomms10682
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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