BMJ Open (Aug 2023)
Pleural mesothelioma risk in the construction industry: a case–control study in Italy, 2000–2018
- ,
- Stefania Curti,
- Stefano Mattioli,
- Dario Consonni,
- Sara Piro,
- Lucia Miligi,
- L Mangone,
- Maria Teresa Landi,
- Neil E Caporaso,
- Carolina Mensi,
- L Giovannetti,
- Elisabetta Chellini,
- Elisa Romeo,
- Alessandro Marinaccio,
- Antonella Stura,
- A Martini,
- Giovanni Brandi,
- Carlo Genova,
- M Gangemi,
- M Davoli,
- L Richiardi,
- P Michelozzi,
- G Serio,
- Luigi Vimercati,
- A Caputi,
- Enrica Migliore,
- AC Pesatori,
- L De Maria,
- Veronica Casotto,
- B Dallari,
- M Bonzini,
- U Fedeli,
- Alessandra Binazzi,
- Corrado Negro,
- Antonio Romanelli,
- Francesco Carrozza,
- Domenica Cavone,
- Federico Tallarigo,
- Massimo Melis,
- C Brentisci,
- M Gilardetti,
- C Storchi,
- O Sala,
- V Cacciarini,
- L Ancona,
- Sg Lio,
- G Frasca,
- Mc Giurdanella,
- C Martorana,
- P Rollo,
- E Spata,
- G Dardanoni,
- S Scondotto,
- S Stecchi,
- D Mirabelli,
- P De Michieli,
- Simona Stella,
- Carmela Gioscia,
- Silvia Eccher,
- Stefano Murano,
- Vera Comiati,
- Flavia D'Agostin,
- Lucia Benfatto,
- Iolanda Grappasonni,
- Gabriella Madeo,
- Ilaria Cozzi,
- Staniscia Tommaso,
- Michele Labianca,
- Giuseppe Cascone,
- D Di Marzio,
- S Rugarli,
- C Pascucci,
- A Balestri,
- MC Delfino,
- F Pentimone,
- MR Angius
Affiliations
- Stefania Curti
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Stefano Mattioli
- 1 Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy
- Dario Consonni
- 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- Sara Piro
- 3 Environmental and Occupational Epidemiology Branch - Cancer Risk Factors and Lifestyle Epidemiology Unit, ISPRO - Institute for Prevention, Research, and Cancer Network, Florence, Italy
- Lucia Miligi
- 3 Environmental and Occupational Epidemiology Branch - Cancer Risk Factors and Lifestyle Epidemiology Unit, ISPRO - Institute for Prevention, Research, and Cancer Network, Florence, Italy
- L Mangone
- Maria Teresa Landi
- 13 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- Neil E Caporaso
- 13 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- Carolina Mensi
- 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- L Giovannetti
- 1Azienda Usl Toscana Centro, Pharmacovigilance, Florence, Italy
- Elisabetta Chellini
- 11 Unit of Environmental and Occupational Epidemiology, COR Tuscany, Cancer Prevention and Research Institute, Firenze, Italy
- Elisa Romeo
- 9 Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
- Alessandro Marinaccio
- 2 Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Rome, Italy
- Antonella Stura
- COR Piemonte, Cancer Epidemiology Unit, CPO and University of Turin, Turin, Italy
- A Martini
- 9Institut Gaslini, Genova, Italy
- Giovanni Brandi
- Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy
- Carlo Genova
- Lung Cancer Unit, IRCCS Ospedal Policlinico San Martino, Genova, Italy
- M Gangemi
- M Davoli
- Department of Epidemiology of the Regional Health Service, Lazio Region, Italy
- L Richiardi
- Cancer Epidemiology Unit, University of Turin, Torino, Italy
- P Michelozzi
- Agency for Public Health Lazio region, Rome, Italy
- G Serio
- Department of Pathology, Medical School, University of Bari, Bari, Italy
- Luigi Vimercati
- 6 Interdisciplinary Department of Medicine (DIM), Unit of Occupational Medicine, University of Bari, Bari, Italy
- A Caputi
- Policlinico Universitario, Messina
- Enrica Migliore
- 3AOU Città della Salute e della Scienza, CPO Piemonte, Turin, Italy
- AC Pesatori
- 1Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- L De Maria
- 1Interdisciplinary Department of Medicine, Occupational Medicine ‘B.Ramazzini’, University of Bari Medical School, Bari, Italy
- Veronica Casotto
- statistician
- B Dallari
- 1Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- M Bonzini
- 1EPIGET Lab – Dept. Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
- U Fedeli
- 2Epidemiological Department, Veneto Region, Padova, Italy
- Alessandra Binazzi
- 1 Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Rome, Italy
- Corrado Negro
- 9 Clinical Unit of Occupational Medicine, COR Friuli-Venezia Giulia, University of Trieste – Trieste General Hospitals, Trieste, Italy
- Antonio Romanelli
- 10 Health Local Unit, Public Health Department, COR Emilia-Romagna, Reggio Emilia, Italy
- Francesco Carrozza
- 18 Oncology Unit, COR Molise, Cardarelli Hospital, Campobasso, Italy
- Domenica Cavone
- 20 Department of Interdisciplinary Medicine, Section of Occupational Medicine ’B.Ramazzini`, COR Puglia, University of Bari, Firenze, Italy
- Federico Tallarigo
- 22 Public Health Unit, COR Calabria, Crotone, Italy
- Massimo Melis
- 24 COR Sardegna, Regional Epidemiological Centre, Cagliari, Italy
- C Brentisci
- M Gilardetti
- C Storchi
- O Sala
- V Cacciarini
- L Ancona
- Sg Lio
- G Frasca
- Mc Giurdanella
- C Martorana
- P Rollo
- E Spata
- G Dardanoni
- S Scondotto
- S Stecchi
- D Mirabelli
- 1 Mesothelioma Registry of Piedmont, Centre for Cancer Epidemiology and Prevention, CPO Piemonte, Turin, Italy
- P De Michieli
- Simona Stella
- 1Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- Carmela Gioscia
- COR Valle d’Aosta, Valle d’Aosta Health Local Unit, Aosta, Italy
- Silvia Eccher
- COR Province of Trento, Provincial Unit of Health, Hygiene and Occupational Medicine, Trento, Italy
- Stefano Murano
- COR Province of Bolzano, Alto Adige Health Local Unit, Bolzano, Italy
- Vera Comiati
- COR Veneto, Epidemiological Department, Azienda Zero, Padova, Italy
- Flavia D'Agostin
- COR Friuli-Venezia Giulia, Clinical Unit of Occupational Medicine, University of Trieste—Trieste General Hospitals, Trieste, Italy
- Lucia Benfatto
- COR Liguria, UO Epidemiologia Clinica, IRCCS Ospedale Policlinico San Martino, Genova, Liguria, Italy
- Iolanda Grappasonni
- COR Marche, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
- Gabriella Madeo
- COR Umbria, Servizio Prevenzione, Sanità Veterinaria e Sicurezza Alimentare, Regione Umbria, Perugia, Umbria, Italy
- Ilaria Cozzi
- COR Lazio, Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Lazio, Italy
- Staniscia Tommaso
- COR Abruzzo, Abruzzo Regional Health Agency (ASR), Pescara, Italy
- Michele Labianca
- COR Basilicata, Epidemiologic Regional Center, Potenza, Italy
- Giuseppe Cascone
- COR Sicilia, Cancer Registry ASP Ragusa and Sicily Regional Epidemiological Observatory, Ragusa, Italy
- D Di Marzio
- S Rugarli
- C Pascucci
- A Balestri
- MC Delfino
- F Pentimone
- MR Angius
- DOI
- https://doi.org/10.1136/bmjopen-2023-073480
- Journal volume & issue
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Vol. 13,
no. 8
Abstract
Objectives Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers.Design Case–control study.Setting Cases from the National Mesothelioma Registry (2000–2018), controls from three previous case–control studies.Methods We selected male PM incident cases diagnosed in 2000–2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002–2004 and 2012–2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses.Results The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower.Conclusions We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.