BMJ Open (Aug 2023)
Pleural mesothelioma risk in the construction industry: a case–control study in Italy, 2000–2018
- ,
- Stefania Curti,
- Stefano Mattioli,
- Dario Consonni,
- Sara Piro,
- Lucia Miligi,
- L Mangone,
- Maria Teresa Landi,
- Neil E Caporaso,
- Carolina Mensi,
- L Giovannetti,
- Elisabetta Chellini,
- Elisa Romeo,
- Alessandro Marinaccio,
- Antonella Stura,
- A Martini,
- Giovanni Brandi,
- Carlo Genova,
- M Gangemi,
- M Davoli,
- L Richiardi,
- P Michelozzi,
- G Serio,
- Luigi Vimercati,
- A Caputi,
- Enrica Migliore,
- AC Pesatori,
- L De Maria,
- Veronica Casotto,
- B Dallari,
- M Bonzini,
- U Fedeli,
- Alessandra Binazzi,
- Corrado Negro,
- Antonio Romanelli,
- Francesco Carrozza,
- Domenica Cavone,
- Federico Tallarigo,
- Massimo Melis,
- C Brentisci,
- M Gilardetti,
- C Storchi,
- O Sala,
- V Cacciarini,
- L Ancona,
- Sg Lio,
- G Frasca,
- Mc Giurdanella,
- C Martorana,
- P Rollo,
- E Spata,
- G Dardanoni,
- S Scondotto,
- S Stecchi,
- D Mirabelli,
- P De Michieli,
- Simona Stella,
- Carmela Gioscia,
- Silvia Eccher,
- Stefano Murano,
- Vera Comiati,
- Flavia D'Agostin,
- Lucia Benfatto,
- Iolanda Grappasonni,
- Gabriella Madeo,
- Ilaria Cozzi,
- Staniscia Tommaso,
- Michele Labianca,
- Giuseppe Cascone,
- D Di Marzio,
- S Rugarli,
- C Pascucci,
- A Balestri,
- MC Delfino,
- F Pentimone,
- MR Angius
Affiliations
- World Health Organization, Geneva, Switzerland
- Stefania Curti
- 15 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Stefano Mattioli
- 32 Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy
- Dario Consonni
- Occupational Health Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, Italy
- Sara Piro
- COR Toscana, Unit of Environmental and Occupational Epidemiology, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy
- Lucia Miligi
- COR Toscana, Unit of Environmental and Occupational Epidemiology, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy
- L Mangone
- Maria Teresa Landi
- 13 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- Neil E Caporaso
- 13 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
- Carolina Mensi
- Occupational Health Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, Italy
- L Giovannetti
- Elisabetta Chellini
- 3 Environmental and Occupational Epidemiology, Cancer Prevention and Research Institute (ISPO), Firenze, Italy
- Elisa Romeo
- 9 Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
- Alessandro Marinaccio
- Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers` Compensation Authority (INAIL), Rome, Italy
- Antonella Stura
- COR Piemonte, Cancer Epidemiology Unit, CPO and University of Turin, Turin, Italy
- A Martini
- 2PRINTO Coordinating Ctr, Genoa, Italy
- Giovanni Brandi
- Sant`Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
- Carlo Genova
- Lung Cancer Unit, IRCCS Ospedal Policlinico San Martino, Genova, Italy
- M Gangemi
- M Davoli
- L Richiardi
- P Michelozzi
- G Serio
- Luigi Vimercati
- COR Puglia, Section of Occupational Medicine ‘B Ramazzini’, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy
- A Caputi
- Enrica Migliore
- COR Piemonte, Cancer Epidemiology Unit, CPO and University of Turin, Turin, Italy
- AC Pesatori
- L De Maria
- Veronica Casotto
- COR Veneto, Epidemiological Department, Azienda Zero, Padova, Italy
- B Dallari
- M Bonzini
- U Fedeli
- Alessandra Binazzi
- Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), Rome, Italy
- Corrado Negro
- COR Friuli-Venezia Giulia, Clinical Unit of Occupational Medicine, University of Trieste—Trieste General Hospitals, Trieste, Italy
- Antonio Romanelli
- Department of Anaesthesia and Intensive Care, University Hospital `San Giovanni di Dio e Ruggi d’Aragona`, Salerno, Italy
- Francesco Carrozza
- COR Molise, Registri Tumori Regione Molise, Campobasso, Italy
- Domenica Cavone
- COR Puglia, Section of Occupational Medicine ‘B Ramazzini’, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy
- Federico Tallarigo
- COR Calabria, Public Health Unit, Crotone, Italy
- Massimo Melis
- COR Sardegna, Regional Epidemiological Center, Cagliari, Italy
- C Brentisci
- M Gilardetti
- C Storchi
- O Sala
- V Cacciarini
- L Ancona
- Sg Lio
- G Frasca
- Mc Giurdanella
- C Martorana
- P Rollo
- E Spata
- G Dardanoni
- S Scondotto
- S Stecchi
- D Mirabelli
- P De Michieli
- Simona Stella
- Occupational Health Unit, Regional Operating Center of Lombardy (COR Lombardia), Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, Italy
- Carmela Gioscia
- COR Valle d’Aosta, Valle d’Aosta Health Local Unit, Aosta, Italy
- Silvia Eccher
- COR Province of Trento, Provincial Unit of Health, Hygiene and Occupational Medicine, Trento, Italy
- Stefano Murano
- COR Province of Bolzano, Alto Adige Health Local Unit, Bolzano, Italy
- Vera Comiati
- COR Veneto, Epidemiological Department, Azienda Zero, Padova, Italy
- Flavia D'Agostin
- COR Friuli-Venezia Giulia, Clinical Unit of Occupational Medicine, University of Trieste—Trieste General Hospitals, Trieste, Italy
- Lucia Benfatto
- COR Liguria, UO Epidemiologia Clinica, IRCCS Ospedale Policlinico San Martino, Genova, Liguria, Italy
- Iolanda Grappasonni
- COR Marche, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
- Gabriella Madeo
- COR Umbria, Servizio Prevenzione, Sanità Veterinaria e Sicurezza Alimentare, Regione Umbria, Perugia, Umbria, Italy
- Ilaria Cozzi
- COR Lazio, Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, Lazio, Italy
- Staniscia Tommaso
- COR Abruzzo, Abruzzo Regional Health Agency (ASR), Pescara, Italy
- Michele Labianca
- COR Basilicata, Epidemiologic Regional Center, Potenza, Italy
- Giuseppe Cascone
- COR Sicilia, Cancer Registry ASP Ragusa and Sicily Regional Epidemiological Observatory, Ragusa, Italy
- D Di Marzio
- S Rugarli
- C Pascucci
- A Balestri
- MC Delfino
- F Pentimone
- MR Angius
- DOI
- https://doi.org/10.1136/bmjopen-2023-073480
- Journal volume & issue
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Vol. 13,
no. 8
Abstract
Objectives Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers.Design Case–control study.Setting Cases from the National Mesothelioma Registry (2000–2018), controls from three previous case–control studies.Methods We selected male PM incident cases diagnosed in 2000–2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002–2004 and 2012–2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses.Results The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower.Conclusions We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.
