Sublingual use of atropine eye drops for the treatment of clozapine induced sialorrhea

Abstract

Clozapine is the drug of choice for patients with treatment-resistant schizophrenia. However, it has a variety of adverse effects. Sialorrhea is a bothersome side effect that can have an impact on both medical and psychosocial aspects. There is limited literature on the use of 1% atropine eye drops sublingually for the treatment of clozapine-induced sialorrhea (CIS). In this case series, we report three patients of CIS treated successfully with 1% atropine eye drops given sublingually.

Keywords

• atropine
• clozapine
• hypersalivation
• schizophrenia
• sialorrhea