Identification of gasdermin B function in the progression of renal clear cell carcinoma by a pan-cancer analysis

Abstract

Abstract The Gasdermin (GSDM) protein family is critically involved in pyroptosis, which participates in the onset and progression of human malignancies. The exact role and impact of the GSDM family genes in various malignancies, particularly renal clear cell carcinoma (KIRC), is still uncertain. The present results indicated GSDMB gene expression significantly upregulated in individuals with KIRC, whose diagnostic effectiveness was confirmed through ROC analysis. Kaplan–Meier analysis also revealed KIRC patients had poor survival prognosis. The high expression of GSDMB served as an independent risk factor for overall survival (OS) in KIRC, based on multivariate cox analysis for confirmation. A nomogram based on GSDMB expression and clinical characteristics displayed remarkable diagnostic effectiveness for KIRC. Collectively, these findings may shed light on functions of GSDM family genes in tumor progression and offer new directions for future research into their potential as therapeutic targets in various types of tumors. Furthermore, the outcomes of this research highlighted that the prediction of treatment responses in KIRC patients may get improved through in-depth exploration into the impact of GSDMB expression on individuals with KIRC patients.

Keywords

• Pan-cancer
• Gasdermin
• Prognosis
• Progression
• Kidney renal clear cell carcinoma