Bactericidal activities of Sm2O3/ Sb2O3/graphene oxide loaded cellulose acetate film

Abstract

Development of wound bandages with suitable performance to accelerate the healing process. Biocompatible, nontoxic, and thermally stable materials were required to enhance the healing period. Cellulose Acetate (CA) with a different contribution of nanoparticles such as antimony (III) oxide (Sb2O3) and samarium (III) oxide (Sm2O3) as the loaded drug through the film casting method. The tests used include scanning tunneling microscope (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR). The surface morphology of the film samples presents a variety in roughness and porosity with diameters between 3 and 7 μm for Sb2O3@CA. In addition, the good distribution of crystalline materials is represented for the rod shapes Sb2O3/Sm2O3/GO@CA with a diameter between 0.4 and 1 μm. The cell viability measured at extremely low doses was around 118% of the control sample. Then, at a dosage of 3500 g/mL, the viable cells dropped to about 43% when the nanoparticles were loaded into CA.

Keywords

• Cellulose acetate
• Sb2O3
• Sm2O3
• Film casting method
• Antibacterial features