Nature Communications (Jul 2018)
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
- Jacob S. Brenner,
- Daniel C. Pan,
- Jacob W. Myerson,
- Oscar A. Marcos-Contreras,
- Carlos H. Villa,
- Priyal Patel,
- Hugh Hekierski,
- Shampa Chatterjee,
- Jian-Qin Tao,
- Hamideh Parhiz,
- Kartik Bhamidipati,
- Thomas G. Uhler,
- Elizabeth D. Hood,
- Raisa Yu. Kiseleva,
- Vladimir S. Shuvaev,
- Tea Shuvaeva,
- Makan Khoshnejad,
- Ian Johnston,
- Jason V. Gregory,
- Joerg Lahann,
- Tao Wang,
- Edward Cantu,
- William M. Armstead,
- Samir Mitragotri,
- Vladimir Muzykantov
Affiliations
- Jacob S. Brenner
- Pulmonary, Allergy, & Critical Care Division, Department of Medicine, University of Pennsylvania
- Daniel C. Pan
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Jacob W. Myerson
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Oscar A. Marcos-Contreras
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Carlos H. Villa
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Priyal Patel
- Pulmonary, Allergy, & Critical Care Division, Department of Medicine, University of Pennsylvania
- Hugh Hekierski
- Department of Anesthesiology & Critical Care, University of Pennsylvania
- Shampa Chatterjee
- Institute for Environmental Medicine, University of Pennsylvania
- Jian-Qin Tao
- Institute for Environmental Medicine, University of Pennsylvania
- Hamideh Parhiz
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Kartik Bhamidipati
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Thomas G. Uhler
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Elizabeth D. Hood
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Raisa Yu. Kiseleva
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Vladimir S. Shuvaev
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Tea Shuvaeva
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Makan Khoshnejad
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Ian Johnston
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- Jason V. Gregory
- Department of Chemical Engineering and Biointerfaces Institute, University of Michigan
- Joerg Lahann
- Department of Chemical Engineering and Biointerfaces Institute, University of Michigan
- Tao Wang
- Penn Cardiovascular Institute, University of Pennsylvania
- Edward Cantu
- Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania
- William M. Armstead
- Department of Anesthesiology & Critical Care, University of Pennsylvania
- Samir Mitragotri
- School of Engineering & Applied Sciences, Harvard University, Wyss Institute
- Vladimir Muzykantov
- Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-018-05079-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs.
