Frontiers in Medicine (Dec 2024)

Gamma delta T cells in cancer therapy: from tumor recognition to novel treatments

  • Xinyu Luo,
  • Yufan Lv,
  • Jinsai Yang,
  • Rou Long,
  • Jieya Qiu,
  • Yuqi Deng,
  • Guiyang Tang,
  • Chaohui Zhang,
  • Jiale Li,
  • Jianhong Zuo,
  • Jianhong Zuo,
  • Jianhong Zuo,
  • Jianhong Zuo

DOI
https://doi.org/10.3389/fmed.2024.1480191
Journal volume & issue
Vol. 11

Abstract

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Traditional immunotherapies mainly focus on αβ T cell-based strategies, which depend on MHC-mediated antigen recognition. However, this approach poses significant challenges in treating recurrent tumors, as immune escape mechanisms are widespread. γδ T cells, with their ability for MHC-independent antigen presentation, offer a promising alternative that could potentially overcome limitations observed in traditional immunotherapies. These cells play a role in tumor immune surveillance through a unique mechanism of antigen recognition and synergistic interactions with other immune effector cells. In this review, we will discuss the biological properties of the Vδ1 and Vδ2 T subsets of γδ T cells, their immunomodulatory role within the tumor microenvironment, and the most recent clinical advances in γδ T cell-based related immunotherapies, including cell engaging strategies and adoptive cell therapy.

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