EARLY DIAGNOSTICS AND TOTAL GASTRECTOMY OF HEREDITARY DIFFUSE GASTRIC CANCER

Abstract

The case report describes a rare case of hereditary diffuse gastric cancer, associated with a CDH1 gene mutation and reported in the Russian population for the fist time. In february 2013, after a medical genetic counseling in the laboratory of clinical oncogenetics of the Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia the 28 years old patient was applied to due to a family history of gastric cancer. Based on the results of the molecular genetic study, thе mutation in the CDH1 gene was found, which determines the risk of diffuse gastric cancer during life beyond 80 %. Histological examination of the material of the gastric mucosa biopsy performed during the esophagogastroduodenoscopy revealed single foci of the ring-cell cancer in the intrinsic plate of the gastric mucosa. In the department of abdominal oncology, the Research Institute of Clinical Oncology of the N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia a splash-preserving gastrectomy for Roux was performed with the formation of a small intestine tank, lymphodissection D2.

Keywords

• hereditary diffuse gastric cancer
• cdh1 gene
• gastrectomy
• molecular-genetic analysis