npj Digital Medicine (Jun 2020)

The Project Baseline Health Study: a step towards a broader mission to map human health

  • Kristine Arges,
  • Themistocles Assimes,
  • Vikram Bajaj,
  • Suresh Balu,
  • Mustafa R. Bashir,
  • Laura Beskow,
  • Rosalia Blanco,
  • Robert Califf,
  • Paul Campbell,
  • Larry Carin,
  • Victoria Christian,
  • Scott Cousins,
  • Millie Das,
  • Marie Dockery,
  • Pamela S. Douglas,
  • Ashley Dunham,
  • Julie Eckstrand,
  • Dominik Fleischmann,
  • Emily Ford,
  • Elizabeth Fraulo,
  • John French,
  • Sanjiv S. Gambhir,
  • Geoffrey S. Ginsburg,
  • Robert C. Green,
  • Francois Haddad,
  • Adrian Hernandez,
  • John Hernandez,
  • Erich S. Huang,
  • Glenn Jaffe,
  • Daniel King,
  • Lynne H. Koweek,
  • Curtis Langlotz,
  • Yaping J. Liao,
  • Kenneth W. Mahaffey,
  • Kelly Marcom,
  • William J. Marks,
  • David Maron,
  • Reid McCabe,
  • Shannon McCall,
  • Rebecca McCue,
  • Jessica Mega,
  • David Miller,
  • Lawrence H. Muhlbaier,
  • Rajan Munshi,
  • L. Kristin Newby,
  • Ezra Pak-Harvey,
  • Bray Patrick-Lake,
  • Michael Pencina,
  • Eric D. Peterson,
  • Fatima Rodriguez,
  • Scarlet Shore,
  • Svati Shah,
  • Steven Shipes,
  • George Sledge,
  • Susie Spielman,
  • Ryan Spitler,
  • Terry Schaack,
  • Geeta Swamy,
  • Martin J. Willemink,
  • Charlene A. Wong

DOI
https://doi.org/10.1038/s41746-020-0290-y
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 10

Abstract

Read online

Abstract The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical information system that accounts for the highly complex interplay of biological, behavioral, environmental, and social systems. The PBHS is a prospective, multicenter, longitudinal cohort study that aims to enroll thousands of participants with diverse backgrounds who are representative of the entire health spectrum. Enrolled participants will be evaluated serially using clinical, molecular, imaging, sensor, self-reported, behavioral, psychological, environmental, and other health-related measurements. An initial deeply phenotyped cohort will inform the development of a large, expanded virtual cohort. The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis.