Nature Communications (Mar 2022)
Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil
- Michel S. Naslavsky,
- Marilia O. Scliar,
- Guilherme L. Yamamoto,
- Jaqueline Yu Ting Wang,
- Stepanka Zverinova,
- Tatiana Karp,
- Kelly Nunes,
- José Ricardo Magliocco Ceroni,
- Diego Lima de Carvalho,
- Carlos Eduardo da Silva Simões,
- Daniel Bozoklian,
- Ricardo Nonaka,
- Nayane dos Santos Brito Silva,
- Andreia da Silva Souza,
- Heloísa de Souza Andrade,
- Marília Rodrigues Silva Passos,
- Camila Ferreira Bannwart Castro,
- Celso T. Mendes-Junior,
- Rafael L. V. Mercuri,
- Thiago L. A. Miller,
- Jose Leonel Buzzo,
- Fernanda O. Rego,
- Nathalia M. Araújo,
- Wagner C. S. Magalhães,
- Regina Célia Mingroni-Netto,
- Victor Borda,
- Heinner Guio,
- Carlos P. Rojas,
- Cesar Sanchez,
- Omar Caceres,
- Michael Dean,
- Mauricio L. Barreto,
- Maria Fernanda Lima-Costa,
- Bernardo L. Horta,
- Eduardo Tarazona-Santos,
- Diogo Meyer,
- Pedro A. F. Galante,
- Victor Guryev,
- Erick C. Castelli,
- Yeda A. O. Duarte,
- Maria Rita Passos-Bueno,
- Mayana Zatz
Affiliations
- Michel S. Naslavsky
- Human Genome and Stem Cell Research Center, University of São Paulo
- Marilia O. Scliar
- Human Genome and Stem Cell Research Center, University of São Paulo
- Guilherme L. Yamamoto
- Human Genome and Stem Cell Research Center, University of São Paulo
- Jaqueline Yu Ting Wang
- Human Genome and Stem Cell Research Center, University of São Paulo
- Stepanka Zverinova
- Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen
- Tatiana Karp
- Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen
- Kelly Nunes
- Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo
- José Ricardo Magliocco Ceroni
- Human Genome and Stem Cell Research Center, University of São Paulo
- Diego Lima de Carvalho
- Human Genome and Stem Cell Research Center, University of São Paulo
- Carlos Eduardo da Silva Simões
- Human Genome and Stem Cell Research Center, University of São Paulo
- Daniel Bozoklian
- Human Genome and Stem Cell Research Center, University of São Paulo
- Ricardo Nonaka
- Human Genome and Stem Cell Research Center, University of São Paulo
- Nayane dos Santos Brito Silva
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Andreia da Silva Souza
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Heloísa de Souza Andrade
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Marília Rodrigues Silva Passos
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Camila Ferreira Bannwart Castro
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Celso T. Mendes-Junior
- Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo
- Rafael L. V. Mercuri
- Centro de Oncologia Molecular, Hospital Sirio-Libanes
- Thiago L. A. Miller
- Centro de Oncologia Molecular, Hospital Sirio-Libanes
- Jose Leonel Buzzo
- Centro de Oncologia Molecular, Hospital Sirio-Libanes
- Fernanda O. Rego
- Centro de Oncologia Molecular, Hospital Sirio-Libanes
- Nathalia M. Araújo
- Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Wagner C. S. Magalhães
- Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Regina Célia Mingroni-Netto
- Human Genome and Stem Cell Research Center, University of São Paulo
- Victor Borda
- Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Heinner Guio
- Laboratorio de Biotecnologia y Biologia Molecular, Instituto Nacional de Salud
- Carlos P. Rojas
- Laboratorio de Biotecnologia y Biologia Molecular, Instituto Nacional de Salud
- Cesar Sanchez
- Laboratorio de Biotecnologia y Biologia Molecular, Instituto Nacional de Salud
- Omar Caceres
- Laboratorio de Biotecnologia y Biologia Molecular, Instituto Nacional de Salud
- Michael Dean
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Mauricio L. Barreto
- Instituto de Saúde Coletiva, Universidade Federal da Bahia
- Maria Fernanda Lima-Costa
- Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz
- Bernardo L. Horta
- Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas
- Eduardo Tarazona-Santos
- Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
- Diogo Meyer
- Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo
- Pedro A. F. Galante
- Centro de Oncologia Molecular, Hospital Sirio-Libanes
- Victor Guryev
- Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen
- Erick C. Castelli
- São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine
- Yeda A. O. Duarte
- Medical-Surgical Nursing Department, School of Nursing, University of São Paulo
- Maria Rita Passos-Bueno
- Human Genome and Stem Cell Research Center, University of São Paulo
- Mayana Zatz
- Human Genome and Stem Cell Research Center, University of São Paulo
- DOI
- https://doi.org/10.1038/s41467-022-28648-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Whole genome sequencing (WGS) data on non-European and admixed individuals remains scarce. Here, the authors analyse WGS data from 1,171 admixed elderly Brazilians from a census cohort, characterising population-specific genetic variation and exploring the clinical utility of this expanded dataset.
