Gliosarcoma Transforming from Giant Cell Glioblastoma: A Case Report and Review of the Literature

Abstract

Giant cell glioblastoma and gliosarcoma are rare histological variants of glioblastoma multiforme. These are WHO Grade IV astrocytic tumors. While giant cell glioblastoma can be seen at younger age, gliosarcoma typically presents at age 40-60 years. Gliosarcoma has a worse prognosis than giant cell glioblastoma. Here, we report a case of giant cell glioblastoma transforming to gliosarcoma and review of the literature.

Keywords

• giant cell glioblastoma
• gliosarcoma
• glioblastoma multiforme
• transformation