The immune landscape of human thymic epithelial tumors

Zhongwei Xin; Mingjie Lin; Zhixing Hao; Di Chen; Yongyuan Chen; Xiaoke Chen; Xia Xu; Jinfan Li; Dang Wu; Ying Chai; Pin Wu

doi:10.1038/s41467-022-33170-7

Nature Communications (Sep 2022)

The immune landscape of human thymic epithelial tumors

Zhongwei Xin,
Mingjie Lin,
Zhixing Hao,
Di Chen,
Yongyuan Chen,
Xiaoke Chen,
Xia Xu,
Jinfan Li,
Dang Wu,
Ying Chai,
Pin Wu

Affiliations

Zhongwei Xin: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Mingjie Lin: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Zhixing Hao: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Di Chen: Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Yongyuan Chen: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Xiaoke Chen: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Xia Xu: Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Jinfan Li: Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Dang Wu: Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Ying Chai: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University
Pin Wu: Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University

DOI: https://doi.org/10.1038/s41467-022-33170-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Thymic epithelial tumours represent a heterogenous group of malignancies with varied immune cell infiltration and prognosis. Here authors systematically analyze the phenotypes of both epithelial and immune cells that form these tumours, and identify three major subtypes with different T cell involvement that might affect prognosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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