Nature Communications (Dec 2016)
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
- Keisuke Katsushima,
- Atsushi Natsume,
- Fumiharu Ohka,
- Keiko Shinjo,
- Akira Hatanaka,
- Norihisa Ichimura,
- Shinya Sato,
- Satoru Takahashi,
- Hiroshi Kimura,
- Yasushi Totoki,
- Tatsuhiro Shibata,
- Mitsuru Naito,
- Hyun Jin Kim,
- Kanjiro Miyata,
- Kazunori Kataoka,
- Yutaka Kondo
Affiliations
- Keisuke Katsushima
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- Atsushi Natsume
- Department of Neurosurgery, Nagoya University School of Medicine
- Fumiharu Ohka
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- Keiko Shinjo
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- Akira Hatanaka
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- Norihisa Ichimura
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- Shinya Sato
- Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
- Satoru Takahashi
- Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
- Hiroshi Kimura
- Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology
- Yasushi Totoki
- Division of Cancer Genomics, National Cancer Center
- Tatsuhiro Shibata
- Division of Cancer Genomics, National Cancer Center
- Mitsuru Naito
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Hyun Jin Kim
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Kanjiro Miyata
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Kazunori Kataoka
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Yutaka Kondo
- Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences
- DOI
- https://doi.org/10.1038/ncomms13616
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation genes, and that targeting TUG1 represses glioma growth in vivo.
