Frontiers in Immunology (Jul 2024)

The therapeutic potential of exosomes in immunotherapy

  • Guangyao Li,
  • Guangyao Li,
  • Shuyi Zhang,
  • Yitan Zou,
  • Yitan Zou,
  • Hongru Ai,
  • Xinya Zheng,
  • Kewen Qian,
  • Changhai Lei,
  • Wenyan Fu

DOI
https://doi.org/10.3389/fimmu.2024.1424081
Journal volume & issue
Vol. 15

Abstract

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Exosomes are found in various tissues of the body and carry abundant contents including nucleic acids, proteins, and metabolites, which continuously flow between cells of various tissues and mediate important intercellular communication. In addition, exosomes from different cellular sources possess different physiopathological immunomodulatory effects, which are closely related to the immune regeneration of normal or abnormal organs and tissues. Here, we focus on the mechanistic interactions between exosomes and the human immune system, introduce the immuno-regenerative therapeutic potential of exosomes in common clinical immune-related diseases, such as infectious diseases, autoimmune diseases, and tumors, and reveal the safety and efficacy of exosomes as a novel cell-free immune regenerative therapy.

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