Nature Communications (Jul 2020)
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
- Dominik Glodzik,
- Ana Bosch,
- Johan Hartman,
- Mattias Aine,
- Johan Vallon-Christersson,
- Christel Reuterswärd,
- Anna Karlsson,
- Shamik Mitra,
- Emma Niméus,
- Karolina Holm,
- Jari Häkkinen,
- Cecilia Hegardt,
- Lao H. Saal,
- Christer Larsson,
- Martin Malmberg,
- Lisa Rydén,
- Anna Ehinger,
- Niklas Loman,
- Anders Kvist,
- Hans Ehrencrona,
- Serena Nik-Zainal,
- Åke Borg,
- Johan Staaf
Affiliations
- Dominik Glodzik
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Ana Bosch
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Johan Hartman
- Department of Oncology and Pathology, Karolinska Institute
- Mattias Aine
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Johan Vallon-Christersson
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Christel Reuterswärd
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Anna Karlsson
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Shamik Mitra
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Emma Niméus
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Karolina Holm
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Jari Häkkinen
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Cecilia Hegardt
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Lao H. Saal
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Christer Larsson
- Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Medicon Village
- Martin Malmberg
- Department of Oncology, Skåne University Hospital
- Lisa Rydén
- Division of Surgery, Department of Clinical Sciences, Lund University
- Anna Ehinger
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Niklas Loman
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Anders Kvist
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Hans Ehrencrona
- Department of Genetics and Pathology, Laboratory Medicine, Region Skåne
- Serena Nik-Zainal
- Academic Department of Medical Genetics, The Clinical School University of Cambridge
- Åke Borg
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- Johan Staaf
- Division of Oncology, Department of Clinical Sciences Lund, Lund University, Medicon Village
- DOI
- https://doi.org/10.1038/s41467-020-17537-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.
