Nature Communications (Mar 2021)
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
Abstract
Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of polyketides.