Nature Communications (Mar 2021)

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

  • Eric J. N. Helfrich,
  • Reiko Ueoka,
  • Marc G. Chevrette,
  • Franziska Hemmerling,
  • Xiaowen Lu,
  • Stefan Leopold-Messer,
  • Hannah A. Minas,
  • Adrien Y. Burch,
  • Steven E. Lindow,
  • Jörn Piel,
  • Marnix H. Medema

DOI
https://doi.org/10.1038/s41467-021-21163-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of polyketides.