Synthesis, characterization and antibacterial activity of new salicylhydrazide containing azopyrazoles

Abstract

Various ethyl-2-substituted phenyl hydrazono-3-oxobutyrate (2a-h) condensation with 2-hydroxy benzoic acid hydrazide (3) to afford 1-(2-hydroxybenzoyl)-3-methyl-4-(2- substituted phenyl hydrazono)-1H-pyrazol-5(4H)-one (4a-h). The structures of all these compounds (4a-h) were recognized on basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antimicrobial activity against various bacteria and fungi.

Keywords

• pyrazoline-5-one
• salicylhydrazide
• antimicrobial activity
• spectral studies