Breast (Jun 2024)
Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology
- Gitte Zels,
- Karen Van Baelen,
- Maxim De Schepper,
- Kristien Borremans,
- Tatjana Geukens,
- Edoardo Isnaldi,
- Hava Izci,
- Sophia Leduc,
- Amena Mahdami,
- Marion Maetens,
- Ha Linh Nguyen,
- Anirudh Pabba,
- François Richard,
- Josephine Van Cauwenberge,
- Ann Smeets,
- Ines Nevelsteen,
- Patrick Neven,
- Hans Wildiers,
- Wouter Van Den Bogaert,
- Giuseppe Floris,
- Christine Desmedt
Affiliations
- Gitte Zels
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, UZ Leuven, Belgium
- Karen Van Baelen
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium
- Maxim De Schepper
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Department of Pathology, UZ Leuven, Belgium
- Kristien Borremans
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium
- Tatjana Geukens
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; General Medical Oncology Unit, Department of Oncology, University Hospitals Leuven, Belgium
- Edoardo Isnaldi
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Hava Izci
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Sophia Leduc
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Amena Mahdami
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Marion Maetens
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Ha Linh Nguyen
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Anirudh Pabba
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- François Richard
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium
- Josephine Van Cauwenberge
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium
- Ann Smeets
- Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium
- Ines Nevelsteen
- Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium
- Patrick Neven
- Gynecological Oncology Unit, Department of Gynecology, University Hospitals Leuven, Belgium
- Hans Wildiers
- General Medical Oncology Unit, Department of Oncology, University Hospitals Leuven, Belgium
- Wouter Van Den Bogaert
- Department of Forensic Medicine, University Hospitals Leuven, Leuven, Belgium
- Giuseppe Floris
- Department of Pathology, UZ Leuven, Belgium; Laboratory for Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium
- Christine Desmedt
- Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium; Corresponding author. Laboratory for Translational Breast Cancer Research Department of Oncology, KU Leuven Herestraat 49, box 808, 3000, Leuven, Belgium.
- Journal volume & issue
-
Vol. 75
p. 103732
Abstract
Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.
