Frontiers in Chemistry (Sep 2022)

Insights into AIE materials: A focus on biomedical applications of fluorescence

  • Junchi Ma,
  • Junchi Ma,
  • Yanru Gu,
  • Yanru Gu,
  • Depeng Ma,
  • Depeng Ma,
  • Weizhao Lu,
  • Weizhao Lu,
  • Jianfeng Qiu,
  • Jianfeng Qiu

DOI
https://doi.org/10.3389/fchem.2022.985578
Journal volume & issue
Vol. 10

Abstract

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Aggregation-induced emission (AIE) molecules have garnered considerable interest since its first appearance in 2001. Recent studies on AIE materials in biological and medical areas have demonstrated that they show their promise as biomaterials for bioimaging and other biomedical applications. Benefiting from significant advantages of their high sensitivity, excellent photostability, and good biocompatibility, AIE-based materials provide dramatically improved analytical capacities for in vivo detection and demonstration of vital biological processes. Herein, we introduce the development history of AIE molecules and recent progress in areas of biotesting and bioimaging. Additionally, this review also offers an outlook for the potential applications of versatile AIE materials for tracing and treating pathological tissues, including overcoming challenges and feasible solutions.

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