Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

M.L. Castellani; E. Toniato; P. Felaco; C. Ciampoli; D. De Amicis; C. Orso; C. Cucurullo; J. Vecchiet; S. Tetè; V. Salini; A. Caraffa; F. Pandolfi; P.L. Antinolfi; G. Cerulli; F. Conti; M. Fulcheri; G. Sabatino; P. Boscolo; Y.B. Shaik

doi:10.1177/1721727X0900700309

European Journal of Inflammation (Sep 2009)

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

M.L. Castellani,
E. Toniato,
P. Felaco,
C. Ciampoli,
D. De Amicis,
C. Orso,
C. Cucurullo,
J. Vecchiet,
S. Tetè,
V. Salini,
A. Caraffa,
F. Pandolfi,
P.L. Antinolfi,
G. Cerulli,
F. Conti,
M. Fulcheri,
G. Sabatino,
P. Boscolo,
Y.B. Shaik

Affiliations

M.L. Castellani: Immunology Division, University of Chieti, Chieti, Italy
E. Toniato: Immunology Division, University of Chieti, Chieti, Italy
P. Felaco: Division of Nephrology, University of Chieti, Chieti, Italy
C. Ciampoli: Clinic of Infectious Diseases, Medical School, University of Chieti-Pescara, Chieti, Italy
D. De Amicis: Department of Human Dynamics, University of Chieti-Pescara, Italy
C. Orso: Department of Human Dynamics, University of Chieti-Pescara, Italy
C. Cucurullo: Division of Medical Pathology, University of Chieti, Italy
J. Vecchiet: Clinical of Infectious Diseases, Medical School, University of Chieti-Pescara, Chieti, Italy
S. Tetè: Dental School, University of Chieti-Pescara, Chieti, Italy
V. Salini: Department of Human Dynamics, University of Chieti-Pescara, Italy
A. Caraffa: Orthopaedics Division, University of Perugia, Perugia, Italy
F. Pandolfi: Catholic University, Rome, Italy
P.L. Antinolfi: Orthopaedics Division, University of Perugia, Perugia, Italy
G. Cerulli: Orthopaedics Division, University of Perugia, Perugia, Italy
F. Conti: Gynecology Division, University of Chieti, Chieti, Italy
M. Fulcheri: Department of Clinical Psychology, University of Chieti-Pescara, Italy
G. Sabatino: Department of Paediatrics, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy
P. Boscolo: Department of Biomedical Science, University of Chieti, Chieti, Italy
Y.B. Shaik: Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

DOI: https://doi.org/10.1177/1721727X0900700309
Journal volume & issue: Vol. 7

Abstract

Read online

IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source of IL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases.

Published in European Journal of Inflammation

ISSN: 1721-727X (Print); 2058-7392 (Online)
Publisher: SAGE Publishing
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://journals.sagepub.com/home/eji

About the journal