Diagnostic Performance of Bronchoalveolar Lavage (1,3)-β-<span style="font-variant: small-caps">d</span>-Glucan Assay for <i>Pneumocystis jirovecii</i> Pneumonia

Abstract

We evaluated the performance of the (1,3)-β-d-glucan (BDG) assay on bronchoalveolar lavage fluid (BALF) as a possible aid to the diagnosis of Pneumocystis jirovecii pneumonia. BALF samples from 18 patients with well-characterized proven, probable, and possible Pneumocystis pneumonia and 18 well-matched controls were tested. We found that the best test performance was observed with a cut-off value of 128 pg/mL; receiver operating characteristic/area under the curve (ROC/AUC) was 0.70 (95% CI 0.52–0.87). Sensitivity and specificity were 78% and 56%, respectively; positive predictive value was 64%, and negative predictive value was 71%. The low specificity that we noted limits the utility of BALF BDG as a diagnostic tool for Pneumocystis pneumonia.

Keywords

• <i>Pneumocystis</i> pneumonia
• d-glucan%22%2C%22default_operator%22%3A%22AND%22%7D%7D%7D"> β-<span style="font-variant: small-caps">d</span>-glucan
• bronchoalveolar lavage fluid