Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Shuting Zhao; Zhaobin Xu; Hai Wang; Benjamin E. Reese; Liubov V. Gushchina; Meng Jiang; Pranay Agarwal; Jiangsheng Xu; Mingjun Zhang; Rulong Shen; Zhenguo Liu; Noah Weisleder; Xiaoming He

doi:10.1038/ncomms13306

Nature Communications (Oct 2016)

Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Shuting Zhao,
Zhaobin Xu,
Hai Wang,
Benjamin E. Reese,
Liubov V. Gushchina,
Meng Jiang,
Pranay Agarwal,
Jiangsheng Xu,
Mingjun Zhang,
Rulong Shen,
Zhenguo Liu,
Noah Weisleder,
Xiaoming He

Affiliations

Shuting Zhao: Department of Biomedical Engineering, The Ohio State University
Zhaobin Xu: Davis Heart and Lung Research Institute, The Ohio State University
Hai Wang: Department of Biomedical Engineering, The Ohio State University
Benjamin E. Reese: Department of Biomedical Engineering, The Ohio State University
Liubov V. Gushchina: Davis Heart and Lung Research Institute, The Ohio State University
Meng Jiang: Davis Heart and Lung Research Institute, The Ohio State University
Pranay Agarwal: Department of Biomedical Engineering, The Ohio State University
Jiangsheng Xu: Department of Biomedical Engineering, The Ohio State University
Mingjun Zhang: Department of Biomedical Engineering, The Ohio State University
Rulong Shen: Department of Pathology, The Ohio State University
Zhenguo Liu: Davis Heart and Lung Research Institute, The Ohio State University
Noah Weisleder: Davis Heart and Lung Research Institute, The Ohio State University
Xiaoming He: Department of Biomedical Engineering, The Ohio State University

DOI: https://doi.org/10.1038/ncomms13306
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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