Expression of GPNMB, ERK, MMP3 and MMP9 in Primary Lesion and Bone Metastasis of Renal Cell Carcinoma and Their Correlation

Abstract

Objective To investigate the expression and significance of GPNMB, ERK, MMP3 and MMP9 in primary lesion and bone metastasis of renal cell carcinoma, and to analyze their correlation. Methods The expression of GPNMB, ERK, MMP3 and MMP9 in primary lesion and bone metastases of renal cell carcinoma were detected by immunohistochemistry. The correlation of GPNMB expression with the clinical pathological features of renal cell carcinoma patients with bone metastasis was analyzed. Results GPNMB expression in primary tumor and bone metastasis were 3.65±1.87 and 5.91±3.68. There were 4, 1 and 3 cases of axial, appendicular and both axial and appendicular bone metastasis in the high GPNMB expression group, while there were 10, 5 and 0 cases in low expression group, respectively(P=0.035). The expression of ERK, MMP3 and MMP9 between the high and low GPNMB expression groups in primary tumor were 7.25±2.55 vs. 2.47±0.64, 5.25±1.91 vs. 2.33±0.49 and 7.00±2.98 vs. 2.27±0.46; while they were 7.45±3.67 vs. 3.75±1.66, 6.45±2.62 vs. 3.25±0.75 and 7.27±3.66 vs. 3.42±0.67 between the high and low GPNMB expression groups in bone metastasis (all P < 0.05). Conclusion The expression of GPNMB in the primary lesion of renal cell carcinoma could predict the extent of bone metastasis. The high expression of GPNMB in primary lesion and bone metastases of renal cell carcinoma is associated with high expression of ERK, MMP3 and MMP9.

Keywords

• renal cell carcinoma
• bone metastasis
• gpnmb
• erk
• mmp3
• mmp9