Nature Communications (Feb 2017)

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability

  • Anatoliy Shumilov,
  • Ming-Han Tsai,
  • Yvonne T. Schlosser,
  • Anne-Sophie Kratz,
  • Katharina Bernhardt,
  • Susanne Fink,
  • Tuba Mizani,
  • Xiaochen Lin,
  • Anna Jauch,
  • Josef Mautner,
  • Annette Kopp-Schneider,
  • Regina Feederle,
  • Ingrid Hoffmann,
  • Henri-Jacques Delecluse

DOI
https://doi.org/10.1038/ncomms14257
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Infection with Epstein–Barr virus (EBV) is associated with increased risk of cancer development. Here the authors show that EBV particles, and more specifically the viral protein BNRF1, induce centrosome amplification and chromosomal instability in host cells in the absence of chronic infection.