Recent Progress in Biosensors for Detection of Tumor Biomarkers
Mantong Li,
Feng Jiang,
Liangyi Xue,
Cheng Peng,
Zhengzheng Shi,
Zheng Zhang,
Jia Li,
Yupeng Pan,
Xinya Wang,
Chunqiong Feng,
Dongfang Qiao,
Zhenzhong Chen,
Qizhi Luo,
Xuncai Chen
Affiliations
Mantong Li
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Feng Jiang
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Liangyi Xue
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Cheng Peng
Guangzhou Institute of Food Inspection, Guangzhou 510080, China
Zhengzheng Shi
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Zheng Zhang
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Jia Li
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Yupeng Pan
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Xinya Wang
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Chunqiong Feng
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Dongfang Qiao
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Zhenzhong Chen
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Qizhi Luo
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Xuncai Chen
Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China
Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.
